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Magnetosome chains are recruited to cellular division sites and split by asymmetric septation

Katzmann, Emanuel, Frank D. Müller, Claus Lang, Maxim Messerer, Michael Winklhofer, Jürgen M. Plitzko, and Dirk Schüler (2011), Magnetosome chains are recruited to cellular division sites and split by asymmetric septation, Molecular Microbiology, 82, 1316-1329, doi:10.1111/j.1365-2958.2011.07874.x, Also featured as research highlight in Nature (480, 416-417, Dec 22, 2011) "Splitting a bacterial magnet" and Microcommentary in Mol Microbiol: "Snapping magnetosome chains by asymmetric cell division in magnetotactic bacteria".

Abstract
Magnetotactic bacteria navigate along magnetic field lines using well-ordered chains of membrane-enclosed magnetic crystals, referred to as magnetosomes, which have emerged as model to investigate organelle biogenesis in prokaryotic systems. To become divided and segregated faithfully during cytokinesis, the magnetosome chain has to be properly positioned, cleaved and separated against intrachain magnetostatic forces.

Here we demonstrate that magnetotactic bacteria use dedicated mechanisms to control the position and division of the magnetosome chain, thus maintaining magnetic orientation throughout divisional cycle. Using electron and time-lapse microscopy of synchronized cells of Magnetospirillum gryphiswaldense, we show that magnetosome chains undergo a dynamic pole-to-midcell translocation during cytokinesis. Nascent chains were recruited to division sites also in division-inhibited cells, but not in a mamK mutant, indicating an active mechanism depending upon the actin-like cytoskeletal magnetosome filament. Cryo-electron tomography revealed that both the magnetosome chain and the magnetosome filament are spilt into halves by asymmetric septation and unidirectional indentation, which we interpret in terms of a specific adaptation required to overcome the magnetostatic interactions between separating daughter chains. Our study demonstrates that magnetosome division and segregation is coordinated with cytokinesis and resembles partitioning mechanisms of other organelles and macromolecular complexes in bacteria.
Further information
BibTeX
@article{id1723,
  author = {Emanuel Katzmann and Frank D. M{\"u}ller and Claus Lang and Maxim Messerer and Michael Winklhofer and J{\"u}rgen M. Plitzko and Dirk Sch{\"u}ler},
  journal = {Molecular Microbiology},
  month = {dec},
  note = {Also featured as research highlight in Nature (480, 416-417, Dec 22, 2011) "Splitting a bacterial magnet" and Microcommentary in Mol Microbiol: "Snapping magnetosome chains by asymmetric cell division in magnetotactic bacteria"},
  pages = {1316-1329},
  title = {{Magnetosome chains are recruited to cellular division sites and split by asymmetric septation}},
  volume = {82},
  year = {2011},
  url = {dx.doi.org/10.1038/480416e},
  doi = {10.1111/j.1365-2958.2011.07874.x},
}
EndNote
%0 Journal Article
%A Katzmann, Emanuel
%A Müller, Frank D.
%A Lang, Claus
%A Messerer, Maxim
%A Winklhofer, Michael
%A Plitzko, Jürgen M.
%A Schüler, Dirk
%D 2011
%V 82
%J Molecular Microbiology
%P 1316-1329
%Z Also featured as research highlight in Nature (480, 416-417, Dec 22, 2011) "Splitting a bacterial magnet" and Microcommentary in Mol Microbiol: "Snapping magnetosome chains by asymmetric cell division in magnetotactic bacteria"
%T Magnetosome chains are recruited to cellular division sites and split by asymmetric septation
%U dx.doi.org/10.1038/480416e
%U dx.doi.org/10.1038/nature.2011.9659
%U dx.doi.org/10.1111/j.1365-2958.2011.07866.x
%8 dec
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Printed 15. Dec 2019 04:01